About

CanStaging⁺ has developed by a collaboration between the Northern Ireland Cancer Registry (NICR), the International Agency for Research on Cancer (IARC), the Union for International Cancer Control (UICC), and Cancer Council Queensland (CCQ). The tool is designed to help maximise the availability, standardisation and comparability of cancer staging internationally. The tool provides automatic calculation of the international TNM staging classification versions 7 and 8 for a variety of tumour sites – breast, cervix, liver, lung, oesophagus, ovary, pancreas, prostate, skin melanoma and stomach. Colorectal cancer may be staged using the TNM staging versions 5 and 8. Used with the permission of UICC, Geneva, Switzerland. The tool works best in conjunction with the UICC TNM classification book which can be purchased here. The original sources for this material are listed in references.

The tool also provides automatic calculation of stage for 15 types of childhood cancers using the business rules developed for the Toronto Paediatric Cancer Stage Guidelines. These rules are freely available through the International Association of Cancer Registries website) and have been translated into several languages. The Guidelines recommend disease-specific staging systems for cancers occurring in children, specifically, acute lymphoblastic leukaemia, Hodgkin lymphoma, non-Hodgkin lymphoma, neuroblastoma, renal tumours (excluding renal cell carcinoma), rhabdomyosarcoma, non-rhabdomyosarcoma soft tissue sarcoma, malignant bone tumours, retinoblastoma, hepatoblastoma, germ cell tumours (testicular cancer and ovarian cancer), astrocytoma, medulloblastoma and ependymoma. Registries may decide to record stage according to Tier 1 or Tier 2, as appropriate to local circumstances and needs.

Developed, designed, and maintained by Morten Ervik (IARC/CSU), Giulio Napolitano (Previously of NICR), Kenneth Yeung (NICR), Colin Fox (NICR), Abigail Jeyaraj (NICR), Sinead Hawkins (NICR), Freddie Bray (IARC/CSU), Isabelle Soerjomataram (IARC/CSU), Minal Solanki (CCQ), Andy Gordon (CCQ), Joanne Aitken (CCQ), and Anna Gavin (NICR)

The original source for this material is:

• Leslie H. Sobin (Editor), Mary K. Gospodarowicz (Editor), Christian Wittekind (Editor), TNM Classification of Malignant Tumours, 7th Edition, published in 2009 by Wiley-Blackwell.
• James D. Brierley (Editor), Mary K. Gospodarowicz (Editor), Christian Wittekind (Editor), TNM Classification of Malignant Tumours, 8th Edition, published in 2016 by Wiley-Blackwell.
• Piñeros M, Parkin DM, Ward K, Chokunonga E, Ervik M, Farrugia H, Gospodarowicz M, O'Slilivan B, Soerjomataram I, Swaminathan R, Znaor A, Bray F, Brierley J. Essential TNM: a registry tool to reduce gaps in cancer staging information. Lancet Oncol. 2019 Feb;20(2):e103-e111. doi: 10.1016/S1470-2045(18)30897-0.
• Gupta S, Aitken JF, Bartels U, Brierley B, Dolendo M, Friedrich P, Fuentes-Alabi S, Garrido CP, Gatta G, Gospodarowicz M, Gross T, Howard SC, Molyneux E, Moreno F, Pole JD, Pritchard-Jones K, Ramirez O, Ries LAG, Rodriguez-Galindo C, Hee Young Shin, Steliarova-Foucher E, Sung L, Supriyadi E, Swaminathan R, Torode J, Vora T, Kutluk L, Frazier AL. Paediatric cancer stage in population-based cancer registries: the Toronto consensus principles and guidelines. Lancet Oncology 2016; 17(4): e163-e172.
• Gupta S*, Aitken JF*, Bartels U, Bhakta N, Bucurenci M, Brierley JD, De Camargo B, Chokunonga E, Clymer J, Coza D, Fraser C, Fuentes-Alabi S, Gatta G, Gross T, Jakab Z, Kohler B, Kutluk T, Moreno F, Nakata K, Nur S, Parkin DM, Penberthy L, Pole J, Poynter JN, Pritchard-Jones K, Ramirez O, Renner L, Steliarova-Foucher E, Sullivan M, Swaminathan R, Van Eycken L, Vora T, Frazier AL. Development of paediatric non-stage prognosticator guidelines for population-based cancer registries and updates to the 2014 Toronto Paediatric Cancer Stage Guidelines. Lancet Oncology. 2020; 21(9): e444-451. *Joint first authors

This tool has been reproduced with due care. Any inconsistencies with the UICC TNM classification 7th and 8th editions in addition to essential TNM or with the Toronto Paediatric Cancer Stage Guidelines and published errata are unintentional. Neither NICR, IARC, UICC, nor CCQ carry any liability should unforeseen errors emerge. However we would be pleased to receive all comments on any inconsistencies.

Thanks: Lisa Ranaghan (NICR), James Brierley (TNM Core Group, UICC)

COPYRIGHT

• The source code of CanStaging+ is copyright IARC 2021. Released under an open source GNU/GPL license.
• The business rules files are copyright NICR 2021 released under a Creative Commons BY-SA license.
• The business rules files for the Toronto Paediatric Cancer Stage Guidelines are copyright CCQ 2021 released under a Creative Commons BY-SA license.
• Illustrations are copyright UICC.

WARRANTIES, DISCLAIMERS AND LIABILITY LIMITATIONS

THIS TOOL IS PROVIDED \"AS IS\" WITHOUT WARRANTY OR CONDITIONS OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OR CONDITIONS OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, OR NON-INFRINGEMENT.

IARC, THE NICR, AND CCQ ASSUMES NO RESPONSIBILITY FOR ERRORS OR OMISSIONS IN THIS TOOL.

IN NO EVENT SHALL IARC, THE NICR OR CCQ BE LIABLE FOR ANY SPECIAL, INCIDENTAL, INDIRECT OR CONSEQUENTIAL DAMAGES OF ANY KIND, OR ANY DAMAGES WHATSOEVER (INCLUDING WITHOUT LIMITATION, THOSE RESULTING FROM: (1) RELIANCE ON THE MATERIALS PRESENTED, (2) COSTS OF REPLACEMENT GOODS, (3) LOSS OF USE, DATA OR PROFITS, (4) DELAYS OR BUSINESS INTERRUPTIONS, (5) AND ANY THEORY OF LIABILITY, ARISING OUT OF OR IN CONNECTION WITH THE USE OR PERFORMANCE OF INFORMATION) WHETHER OR NOT IARC, THE NICR, OR CCQ HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES.

THIS TOOL COULD INCLUDE TECHNICAL OR OTHER INACCURACIES. HOWEVER, IARC, NICR, AND CCQ MAKES NO COMMITMENT TO PROVIDE UPDATES.